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After Henry's death Catherine read the bible every day for comfort. When she started developing symptoms similar to syphilis, she thought it was a final gift from her husband so she would never forget him or his whores. Later, Lord Narcisse realizes she must have been poisoned instead since there weren't enough similarities. Catherine soon realized that it must have been the bible and she tested it for poison and the test came back positive; the Queen then figured out that whoever poisoned the bible caused Henry's madness as well as her own. It is later learned that not only did Narcisse pay someone to poison the bible for him, he also framed Christian de Guise for the crime.